Oligonucleotides are short nucleic acid polymers used in research,
genetic testing and forensics. Oligonucleotides are usually made up of 13 to 25
nucleotides and are designed to hybridize specifically to DNA or RNA sequences.
Solid-phase clinical synthesis is used to manufacture these small bits of
nucleic acid for use in polymerase chain reaction (PCR), DNA sequencing,
library construction and artificial gene synthesis.
Oligonucleotide synthesis is the chemical synthesis of relatively short
fragments of nucleic acids with defined chemical structure/sequence.In the
enzymatic process of DNA synthesis, deoxy-ribonucleotide-5’-tri-phosphates are
used as substrates during polymerization. In addition, this process requires a
primer and a template.
The most frequently used oligonucleotide synthesis strategy is based
upon beta-cyanoethylphosphoramidite chemistry. The synthesis proceeds from the
3’ to the 5’ end of the oligonucleotide, which is in opposition to the
enzymatically catalyzed reaction where polymerization proceeds from 5’- 3’. The
synthesis continues repeating cycle until the sequence of the oligonucleotide
has been built.
Growing R&D spending in pharmaceutical and biotechnology companies,
increased use in clinical applications and molecular diagnostics, growing
government investments for the development of genomics and
developingconsequence of RNA-interference oligos in the therapeutics and
diagnostics are the key factors driving market size for oligonucleotide
synthesis.
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Whereas, high cost of synthesized oligonucleotides and strict regulatory
requirements for the approval of oligonucleotide-based therapeutics are some of
the factors constraining the growth of the global oligonucleotide synthesis
market to some extent. The global Oligonucleotide Synthesis Market is segmented
on the basis of product type, application, and region.
On the basis of product type and services, the global market is classified
into by Product (Synthesized Oligonucleotides, Primers, Probes,
Intermediate-scale synthesis Oligos, Large-scale synthesis Oligos, Linkers and
Adaptors), By Services (Custom Oligos, Pre-designed Oligos, Reagents,
Equipment). Synthesized oligonucleotides segment is expected to account for the
largest market share of oligonucleotide synthesis market. This is due to the
increasing number of applications of synthesized oligonucleotides in research,
diagnostics, and therapeutics. The mounting demand for custom oligos also
subsidizes to the growth of the synthesized oligonucleotides market.
On the basis of application, the global market is classified into
Research, Diagnostics, Therapeutics. Research segment is sub-segmented into
PCR, qPCR, DNA Sequencing, Gene Synthesis, other. Therapeutics is further
sub-segmented into DNA/Antisense oligo’s, RNA, Nucleic acid aptamers,
Immunotherapy Applications.
Research segment accounts for the largest market size of oligonucleotide
synthesis market. Diagnostic segment is likely to grow at highest CAGR during
the forecast period. This is mainly due to the developing application of
molecular diagnostics (MDx) and genetic testing. The growing use of
technologies such as DNA microarrays in the analysis of biological samples and
developing molecular oncology diagnostics tests also subsidize in the growth of
molecular diagnostics market size.
On the basis of end user, the global market size is classified into
Academic Research Institutes, Diagnostic Laboratories, Pharmaceutical and
Biotechnology Companies, Other End Users. Academic research institutes segment
accounts the largest market share of oligonucleotide synthesis market. This is
due to academic researchers mainly use oligonucleotides for various applications
in genetic engineering, polymerase chain reaction (PCR) activities, and
high-throughput sequencing.
Geographically, the global market size is segmented into North America,
China, Europe, Japan, India, and Southeast Asia. North America is expected to
hold the largest market size of global oligonucleotide synthesis market. Asian
market size is expected to grow at the highest CAGR, mainly due to the rising
accessibility of synthesized oligos, along with an increase in R&D funding
and activities in the region. The key players are Agilent Technologies,
Biosearch Technologies, Inc, Eurofins Genomics, Eurogentec, GeneDesign, Inc.,
and Bio-Synthesis - CRO/CMO Life Sciences Company.
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